PF4 anticorps (Biotin)

N° du produit ABIN954174

Cet anticorps anti-PF4 est un anticorps Souris Monoclonal détectant PF4 dans WB et EIA. Adapté pour Humain.

Aperçu rapide pour PF4 anticorps (Biotin) (ABIN954174)

Antigène: PF4 (Platelet Factor 4 (PF4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PF4 est conjugé à/à la Biotin

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: RTO

Détail du produit anti-PF4 anticorps (Biotin)

Specificité: This antibody is specific for Human Platelet Factor IV. AM31850BT-N (clone RTO) is seen to bind free PF4 in the absence of any bound Heparin. This is unlike AM31851BT-N (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT).

Réactivité croisée (Details): Species reactivity (tested):Human.

Immunogène: Human Factor IV purified from the supernatant of Thrombin activated platelets.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PF4

Antigène: PF4 (Platelet Factor 4 (PF4))

Autre désignation: Platelet Factor 4 / PF4

Sujet: Platelet Factor IV (PF4) is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity.Synonyms: C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, PF-4, SCYB4

ID gène: 5196

NCBI Accession: NP_002610

UniProt: P02776